BMJ should use "paracetamol" instead of "acetaminophen" in its index

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Repeated Supratherapeutic Acetaminophen (paracetamol) Use Resulting in a Fatality

In the United States acetaminophen (paracetamol) is the most commonly used nonprescription analgesic. In addition to its nonprescription use, acetaminophen is also a common ingredient of prescription opioid combination products. This case report describes an acetaminophen-related fatality that occurred as a consequence of an unintentional overdose of a prescribed hydrocodone/acetaminophen produ...

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Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

BACKGROUND Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of action, and concern about the possibility of adverse effects on reproductive health. METHODS We first established the metabolome profile that characterizes use of acetaminophen, and we subsequently trained and tested a model t...

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Paracetamol (Acetaminophen): mechanisms of action.

Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors. Prostaglandin H(2) synthetase (PGHS) is the enzyme responsible for metabolism of arachidonic acid to the unsta...

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Acetaminophen (Paracetamol): Use beyond Pain Management and Dose Variability

1 Aspetar – Qatar Orthopaedic and Sports Medicine Hospital, Athlete Health and Performance Research Centre, Doha, Qatar, 2 Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Chatham Maritime, Chatham, United Kingdom, 3 Aspetar – Qatar Orthopaedic and Sports Medicine Hospital, Exercise and Sports Science Department, Doha, Qatar, 4 Aspetar – Qatar Orthopaedic and...

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Colorimetry of serum acetaminophen (paracetamol) in uremia.

A popular colorimetric analysis for serum acetaminophen, based on ring-nitration of the drug, is demonstrated to yield both "false positives" and erroneously high results for serum from uremic patients. The interference appears to be anionic at physiological pH, and correlates significantly with serum creatine concentration and with the magnitude of the "anion gap." A modification of the analys...

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ژورنال

عنوان ژورنال: BMJ

سال: 1996

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.313.7058.689